6 edition of Circulating Nucleic Acids in Plasma/Serum III and Serum Proteomics (Annals of the New York Academy of Sciences) found in the catalog.
August 30, 2004 by New York Academy of Sciences .
Written in English
|Contributions||Dave S. B. Hoon (Editor), Bret Taback (Editor)|
|The Physical Object|
|Number of Pages||325|
Due to the dense packing of Au NPs, the exosomal biomolecules including lipids, proteins, carbohydrates, and even nucleic acids could be detected. The SERS spectrum can be converted to images, with peak intensity yielding material concentration and peak position yielding material structure. Even early during neoadjuvant therapy, methylated RASSF1 in the serum became undetectable in patients with complete pathological response, whereas methylated RASSF1 persisted longer or throughout the treatment in patients who had only partial or minimal pathological response [ 62 ]. Meanwhile, the cantilever served as an optical cavity that boosted the scattering signal from the Au NPs due to plasmonic coupling.
Before implementation of cfDNA analysis into the clinical decision, several issues need to be addressed in future studies: i Because cfDNA represents mainly the genome of dying tumor cells, the time point of blood sampling during the course of a treatment is important to discover genetic alterations present in the resistant tumor cell clones. World J Gastroenterol. This effect depends on the particle size, shape, particle-fluorophore distance, the orientation of the fluorophore with respect to the particle, and the overlap of the emission of the molecule with the particle's absorption spectrum [ 18 ]. High-sensitivity nanosensors for biomarker detection. Also, the abnormal proliferation of benign cells, due to inflammation or tissue repair processes, leads to the accumulation of DNA in the blood and the masking of LOH [ 29 ].
Different combinations of circulating miR, miR, miR, miR, miRb, miRp, and miR have been reported to be valuable biomarkers for distinguishing breast cancer from normal controls [ 77 — 80 ]. Kamynina, Elena V. Detection and quantification of mutations in the plasma of patients with colorectal tumors. The level of heterogeneity might be due to the sample with different time point. If commercialized, this assay will provide a revolutionary platform for low cost and POC detection of serum protein cancer makers in both resource-rich and resource-limited settings.
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Annals of Oncology. The first hairpin initiated the opening of second hairpin and started the HCR process. NOTE: Annals volumes are available for sale as individual books or as a journal. The use of antibodies as the recognition ligands often leads to high false positives as antibodies have nonspecific binding to WBCs.
Of these sources, nucleosomes and virtosomes would appear to form major components of CNAPS [ 1618 ]. A distinguished example was demonstrated by Sim et al. The assay has been automated and tested later on clinical samples that showed its capability to follow serum PSA from recurrent prostate cancer patients under prostatectomy that could not be detected by commercial assays [ ].
It should be mentioned that, despite the ground-breaking nature of this study, the dropout Circulating Nucleic Acids in Plasma/Serum III and Serum Proteomics book was considerable and the analyses were restricted to a small cohort of patients.
This makes it impractical for resource-limited clinical settings. Successful prenatal diagnosis of Down's syndrome by fetal RNA analysis has recently been reported. Detection and monitoring of cell-free DNA in blood of patients with colorectal cancer.
However, majority techniques have been only tested on commercially synthesized oligonucleotides. Ann Surg Oncol. The clearance of cfNAs occurs by degradation and other physiological filtering events of the blood and lymphatic circulation.
KustovValentin V. Similar to ctDNA, circulating RNAs have been successfully evaluated in many types of cancers and emerged as promising biomarkers for cancer diagnosis, staging, prognosis and treatment monitoring [ - ]. This detection mechanism has also been used to detect serum protein markers, as demonstrated by Dai and co-workers who used fluorescence enhancement by nanostructured Au on Au film to Circulating Nucleic Acids in Plasma/Serum III and Serum Proteomics book a new generation protein microarray assay Figure 7 [ ].
These circulating cancer biomarkers offer the possibility of noninvasive cancer screening, early detection, patient prognosis, and enable monitoring of tumor growth and treatment response. Its aberrant promoter hypermethylation may be common among high-risk women, leading to the repression of this scaffold protein that localizes signaling in cells.
Cherdyntseva, and Pavel P. Using this approach, Gevensleben et al. The cffDNA from the plasma of 3 of 25 women with female fetuses contained the Y chromosome-specific signal. For permission for commercial use of this work, please see paragraphs 4.
EXOs and MVs in plasma require purification and enrichment before detection and characterization. However, conventional SPR has several concerns including limited sensitivity, low throughput and difficult miniaturization. The Au nanohole arrays, nm in diameter and nm in periodicity, served as a multiwall plate reader for plasmonic sensing of tens of samples at the same time.
Prognostic value of circulating KRAS2 gene mutations in colorectal cancer with distant metastases. Holford, A. Due to their high sensitivity, good photostability, large working range, and excellent multiplexicity, SERS has become another major method for serum protein marker detection [ - ].Nov 21, · Peter Gahan and R.
Swaminathan are the authors of Annals of the New York Academy of Sciences, VolumeCirculating Nucleic Acids in Plasma and Serum V, published by Wiley. show more Learn about new offers and get more deals by joining our newsletter. Circulating nucleic acids in plasma or serum (CNAPS) as prognostic and predictive markers in patients with solid neoplasias Georg Goebela, Marion Zitt b, Matthias Zitt and Hannes M.
Muller¨ b,∗ aDepartment of Medical Statistics, Informatics and Health Economics,Innsbruck Medical University, A Innsbruck, Austria. Oct 09, · The presence of circulating, cell-free nucleic acids in the bloodstream was first described by Mandel and Métais in .Thirty years later, Leon et al.
showed that patients with breast cancer (BC) display increased serum levels of cell-free DNA (cfDNA) in their blood circulation; they detected a wide DNA range, from 0 to ng/ml, by radioimmunoassay .Cited by: The Second International Symposium on Pdf Nucleic Acids in Plasma and Serum (CNAPS-2) held in conjunction with the 6th Annual Scientific Symposium of the Hong Kong Cancer Institute Hong Kong February 20–21, The Paperback of the Circulating Nucleic Acids in Plasma or Serum II by Lo Y.
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